Lomotil Tablets 2.5mg 20'sHow Lomotil Tablets 2. 5mg with Diphenoxylate HCl and Atropine Sulphate Treat Diarrhea Lomotil Tablets 2. 5mg contain Diphenoxylate HCl, an opioid like medication, and Atropine Sulphate, an anticholinergic. Together, these ingredients work to reduce the movement of the intestines and slow down diarrhea, providing relief from acute symptoms. Key Benefits of Using Lomotil Tablets 2. 5mg 2. 5mg Diphenoxylate HCl and 0. 025mg Atropine Sulphate per tablet